Progress

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Major Development Milestones

February 25, 2025 – Smart mRNA Works!

Smart mRNA turned ON in
cancer cells only

fluorescene-microscopy

Smart mRNA turned OFF
in healthy cell line (HEK293)

fluorescene-microscopy
May 31, 2025 – Successfully Made Cell Targeting Nanoparticle!
lipid-nanoparticle
  • Independent analysis confirmed efficient and successful attachment of Marker1 onto lipid nanoparticles
  • Marker1 is a molecule that will seek out specific proteins on cancer cell surface and deliver our Smart mRNA payload
  • Next step, we will put Smart mRNAs inside the nanoparticles to make complete cancer targeting and killing nanoparticles.
August 5, 2025 – Successfully Disguised Cancer Cells and Tricked Immune Cells into Attacking Them
lipid-nanoparticle

Statistical Difference Between Conditions:

  • nsp>0.05 (not significant)
  • *p<=0.05
  • **p<=0.01
  • ***p<=0.001
  • Non-immunogenic mRNA was used as a Negative Control to confirm little to no T-cell activation by cancer cells alone.
  • Known immunogenic peptides were used as a Positive Control to confirm the expected level of T-cell activation.
  • CancerVax mRNAs disguised cancer cells as measles and Sars-CoV-2, which activated T-cells to similar levels as the Positive Control.
  • The CancerVax trick worked, and worked very well!